Antiangiogenic therapies, though better tolerated than traditional chemotherapy, can produce a number of side effects that require careful monitoring and medical management. Elevated blood pressure (hypertension) is a common class-based side effect of antiangiogenic therapy. Some patients may require blood pressure-lowering medications during their therapy with angiogenesis inhibitors. Excess protein in the urine, called proteinuria, is another common side effect of antiangiogenic therapy, but is usually mild and does not interfere with treatment. Other less common side effects associated with angiogenesis inhibitors include impaired wound healing, gastrointestinal perforations, bleeding and coagulation problems, skin rash, diarrhea, fatigue, and nausea.